Multi-Component Sequential Synthesis of Dihydroorotic Acid-Based Amphiphilic Molecules

Abstract An efficient multicomponent sequential process, which occurs in mild condition has been exploited for the synthesis of systematically modified amphiphilic molecules where cationic head is tethered to a lipophilic tail through dihydroorotic acid linker. The process operatively simple, high yielding, and flexible. Such strategy could impact combinatorial wide libraries be tested as transfection agents and/or antimicrobials.